Molecular modelling of the gastric barrier response, from infection to carcinogenesis

The lining of the stomach is a tight monolayer epithelial cells performing functions in digestion and protective barrier against gastric acid, toxic metabolites infectious agents, including Helicobacter pylori. response to infections underlies pathologies, cancer. H. pylori has unique capacity colonise mucosa while evading immune system. colonised initiates an inflammatory fight infection strong regenerative program avoid failure ulceration. This changes morphology cell composition epithelium parallel it might contribute accumulation somatic mutations leading cellular transformation. Genetically modified mice, lines human-derived organoids are main biological models study barrier. With these possible dissect stepwise process tissue adaptation that places at risk malignant